San Francisco 49ers
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Brock Purdy
Brock Purdy Flexes on lowly Titans
Sun, Dec 14, 2025, 9:35 PM
Purdy completed 23 of 30 pass attempts for 295 yards and three touchdowns while adding seven carries for 44 yards and a lost fumble in Sunday's 37-24 win over the Titans.
Analysis: The 49ers' Week 14 bye did Purdy wonders. In addition to allowing the quarterback's body to gain strength after returning from injury just weeks prior, it also afforded the coaching staff an extra week to gameplan against an inferior opponent. The end result Sunday was the 25-year-old's finest fantasy outing to date in 2025. Purdy will face a stiffer test on the road against the Colts next Monday, but his fantasy arrow is pointing up for Week 16.
Christian McCaffrey
Christian McCaffrey Extends TD streak to four games
Sun, Dec 14, 2025, 8:04 PM
McCaffrey (back) took 22 carries for 73 yards and a touchdown while grabbing his only target for 14 yards in Sunday's 37-24 win over Tennessee.
Analysis: McCaffrey battled an illness and a minor back injury in order to suit up for Sunday's contest, and he looked no worse for wear in the win. The 29-year-old punched in his ninth rushing touchdown of the campaign while extending his scoring streak to four games. CMC was used sporadically as a receiver (one target) for the first time this season after entering the contest with averages of 6.5 receptions on 8.2 targets. Assuming his back injury didn't flare up Sunday, fantasy managers can expect McCaffrey to spearhead San Francisco's offense on the road against Indianapolis on Monday Night Football in Week 16.
Jordan James
Jordan James Remaining healthy scratch Week 15
Sun, Dec 14, 2025, 2:06 PM
James (coach's decision) is inactive for Sunday's matchup against Tennessee.
Analysis: James has yet to make his NFL debut and has consistently been a healthy scratch on gamedays. The rookie fifth-rounder is firmly behind all of Christian McCaffrey, Brian Robinson and Isaac Guerendo on the 49ers' RB depth chart.
Christian McCaffrey
Christian McCaffrey Active versus Titans
Sun, Dec 14, 2025, 2:04 PM
McCaffrey (back) is active for Sunday's game against the Titans.
Analysis: After an illness impacted his practice participation Wednesday and Thursday, McCaffrey worked fully Friday and initially approached Sunday's contest minus a designation. However, on Saturday the running back was added the 49ers' Week 15 injury report due to a back issue. With his availability versus Tennessee confirmed, McCaffrey is back on track to pace his team's backfield in the absence of any in-game setbacks. Next up for San Franciso's backfield touches if McCaffrey is hampered at all would be Brian Robinson and Isaac Guerendo.
Brandon Aiyuk
Brandon Aiyuk Done for 2025
Sat, Dec 13, 2025, 3:45 PM
The 49ers placed Aiyuk (knee) on the reserve/left squad list Saturday, Matt Barrows of The Athletic reports.
Analysis: The move means Aiyuk will not return for the rest of the season and will likely not be a part of the 49ers' plans from 2026 and beyond. Aiyuk has been recovering from ACL and MCL tears in his right knee that he sustained during the 2024 campaign, and it's unclear whether the 49ers will look to trade the 2020 first-rounder during the offseason or cut him from the roster outright.
Christian McCaffrey
Christian McCaffrey Expected to play vs. Tennessee
Sat, Dec 13, 2025, 3:26 PM
Although he was added to the 49ers' injury report Saturday, McCaffrey (back) is expected to play against the Titans on Sunday, Adam Schefter of ESPN reports.
Analysis: McCaffrey popped up on Saturday's injury report due to a back issue, but at this time, the injury isn't considered severe enough for him to miss Sunday's contest. If McCaffrey suffers a setback or operates on a snap count, then Brian Robinson, Isaac Guerendo and Jordan James would be in line for more work out of the 49ers' backfield. McCaffrey's official status may not be announced until the 49ers submit their list of inactive players approximately 90 minutes before the 4:25 p.m. ET kickoff.
Christian McCaffrey
Christian McCaffrey Now questionable for Week 15
Sat, Dec 13, 2025, 2:55 PM
McCaffrey has been added to the 49ers' injury report due to a back injury, and he is listed as questionable for Sunday's game against the Titans, Matt Barrows of The Athletic reports.
Analysis: McCaffrey was able to shake off an illness during Week 15 prep, but the veteran running back appears to be working through a new back issue. The injury puts McCaffrey in jeopardy of missing Sunday's game, and his official status may not be known until the 49ers announce their list of inactive players approximately 90 minutes before the 4:25 p.m. ET kickoff. If McCaffrey is unable to play, then Brian Robinson would likely take over as the 49ers' lead back while Isaac Guerendo and Jordan James provide backfield depth.
Kyle Juszczyk
Kyle Juszczyk Cleared to play Week 15
Fri, Dec 12, 2025, 5:00 PM
Juszczyk (ribs) does not have an injury designation for Sunday's game against the Titans, Cam Inman of The San Jose Mercury News reports.
Analysis: Juszczyk fractured his rib during the 49ers' Week 13 win over the Browns. The veteran fullback had extra time to recovery courtesy of the 49ers' Week 14 bye, and he's been given the green light to play in Sunday's home game. Juszczyk has mostly operated as a backfield blocker on run plays but has also been effective in the passing attack, having hauled in 20 passes (on 23 targets) for 187 yards and a touchdown through 13 regular-season games.
Christian McCaffrey
Christian McCaffrey Cleared after full practice
Fri, Dec 12, 2025, 4:27 PM
McCaffrey (illness) doesn't have an injury designation for Sunday's game against the Titans, Cam Inman of The San Jose Mercury News reports.
Analysis: The 49ers added him to the injury report mid-week due to an illness, but McCaffrey still managed a limited practice Thursday and full session Friday. He should be fine for his usual role this Sunday against the Titans, albeit with higher-than-usual risk of being pulled early from a blowout. Of course, that might be the same scenario in which McCaffrey puts up a ton of points early in the game.
Christian McCaffrey
Christian McCaffrey Practicing Friday
Fri, Dec 12, 2025, 2:54 PM
McCaffrey (illness) is practicing Friday, Noah Furtado of the San Francisco Chronicle reports.
Analysis: The illness apparently isn't serious, considering McCaffrey was a limited practice participant Thursday and is now practicing again Friday. He's on track to play Sunday against the Titans.
Kyle Juszczyk
Kyle Juszczyk Remains limited Thursday
Thu, Dec 11, 2025, 7:08 PM
Juszczyk (ribs) logged a limited practice Thursday.
Analysis: Juszczyk has begun Week 15 prep with consecutive limited practice sessions due to a fractured rib. The fact the veteran fullback has been able to participate in some capacity both Wednesday and Thursday suggests he has a chance of suiting up Sunday against Tennessee, though he may get an injury designation for the contest if he's not able to practice in full Friday. Should Juszczyk have to miss Sunday's game, it would mark his first absence from a regular-season contest since 2022.
Christian McCaffrey
Christian McCaffrey Dealing with illness
Thu, Dec 11, 2025, 4:27 PM
McCaffrey was limited at Thursday's practice due to an illness, David Lombardi of SFStandard.com reports.
Analysis: McCaffrey ranks fifth in the entire NFL with 85 catches and also sits in third with 237 carries through 13 games this season, resulting in 1,655 yards from scrimmage and 13 total TDs. With an illness now in tow, he may need to get back to all activity Friday in order to avoid a designation for Sunday's contest against the Titans. Brian Robinson is the next RB up in San Francisco if McCaffrey cedes any backfield reps this weekend.
Kyle Juszczyk
Kyle Juszczyk Limited by rib injury
Wed, Dec 10, 2025, 11:15 PM
Juszczyk (ribs) logged a limited practice Wednesday.
Analysis: Juszczyk suffered a fractured rib ahead of the 49ers' bye week. That gave him the chance to rest and the opportunity to suit up for the 49ers' Week 15 matchup against the Titans.
Brandon Aiyuk
Brandon Aiyuk Not ruled out from playing in 2025
Tue, Dec 2, 2025, 11:30 AM
San Francisco general manager John Lynch reiterated Tuesday that he's still "hopeful" Aiyuk (knee) will play at some point this season, though Lynch acknowledged that he wasn't sure how realistic the wideout's return might be, Cam Inman of The San Jose Mercury News reports.
Analysis: Lynch noted that Aiyuk is continuing to take part in rehab work for the surgery he underwent last October to address ACL and MCL tears in his right knee, but the 49ers have thus far declined to put out a target date for when the 27-year-old might be ready to practice. As David Lombardi of SFStandard.com suggests, the decision as to whether Aiyuk suits up in 2025 likely falls on the wideout's shoulders. While the 49ers would seemingly welcome him back if he's healthy enough to play, Aiyuk may not be as motivated to suit up after San Francisco voided approximately $26 million in guarantees for the 2026 season back in late July. Aiyuk is still on San Francisco's books through 2028, though the team will likely look to trade him this offseason if it can find a suitor willing to pick up most of his remaining salary. Releasing Aiyuk is another possibility, but the 49ers would incur a dead-cap charge of $29.585 million if he's cut outright without a post-June 1 designation.
Kyle Juszczyk
Kyle Juszczyk Dealing with rib fracture
Mon, Dec 1, 2025, 7:44 PM
Juszczyk is dealing with a rib fracture ahead of the 49ers' bye week, David Lombardi of SFStandard.com reports.
Analysis: Juszczyk sustained the injury in the team's 26-8 win over the Browns on Sunday, and he's expected to be reevaluated after the team is idle in Week 14. The fullback will have a good shot at not missing any action moving forward as a result of the week off.
Kyle Juszczyk
Kyle Juszczyk Further evaluation coming
Mon, Dec 1, 2025, 12:37 PM
Juszczyk will have further evaluation on his ribs injury once the team returns to Santa Clara, Nick Wagoner of ESPN.com reports.
Analysis: Head coach Kyle Shanahan told reporters that initial tests revealed no broken ribs, but Juszczyk will still undergo further testing to determine the extent of his injury. The 49ers have a Week 14 bye, which could allow the 34-year-old fullback enough time to recover ahead of the team's Week 15 matchup against the Titans.
Kendrick Bourne
Kendrick Bourne First target since Week 10
Mon, Dec 1, 2025, 11:29 AM
Bourne was held without a catch (one target) in Sunday's 26-8 win over the Browns.
Analysis: Bourne was targeted for the first time since Week 10 in Sunday's road victory, but he failed to haul in his only opportunity across 23 snaps played on offense (34 percent). The veteran wideout has been relegated to No. 4 on the depth chart ever since Ricky Pearsall returned from a knee injury Week 11. Bourne should remain a fantasy afterthought when the 49ers return from the upcoming bye week to face the Titans on Sunday, Dec. 14.
Demarcus Robinson
Demarcus Robinson Logs first carry of 2025
Mon, Dec 1, 2025, 11:18 AM
Robinson failed to secure his only target while gaining six yards on his first carry of the season in Sunday's 26-8 win over Cleveland.
Analysis: Robinson was limited to one touch for the third straight week, but it came in unorthodox fashion when he handled an end-around for his first carry as a member of the 49ers. The 30-year-old logged 27 snaps on offense (42 percent), maintaining his status as the team's third wideout behind starters Jauan Jennings and Ricky Pearsall. Robinson has been unable to generate noteworthy production in his steady role in an explosive offense, resulting in a meager 13-163-0 receiving line heading into San Francisco's Week 14 bye.
Brian Robinson
Brian Robinson Eight carries in dominant win
Sun, Nov 30, 2025, 7:38 PM
Robinson turned eight carries into 26 yards in Sunday's 26-8 victory over Cleveland.
Analysis: Robinson garnered at least seven carries for the fourth game in a row, but he was limited to an uninspiring 3.3 yards per carry Sunday. The running back also didn't see a target for the first time since Week 9. Robinson has now rushed the ball 72 times for 328 yards and two touchdowns while catching seven of 10 targets for 19 yards over 13 contests this year.
George Kittle
George Kittle Paces Niners in receiving yards
Sun, Nov 30, 2025, 3:47 PM
Kittle caught four of five targets for 67 yards in Sunday's 26-8 win over the Browns.
Analysis: The veteran tight end led the Niners in receiving yards and tied Jauan Jennings for the team lead in catches on a day in which passing was difficult due to high winds in Cleveland. Kittle has caught at least four passes in six straight games, racking up a 33-371-4 line on 39 targets during that stretch. He'll get a breather during San Francisco's bye next week before taking on Tennessee in Week 15.

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